Research programme: LOX inhibitors - Pharmaxis

Drug Profile

Research programme: LOX inhibitors - Pharmaxis

Alternative Names: LOX; LOXL2; PXS 5382A

Latest Information Update: 13 Sep 2017

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At a glance

  • Originator Pharmaxis
  • Developer Pharmaxis; Synairgen
  • Class Antifibrotics; Antineoplastics; Pyrans; Small molecules
  • Mechanism of Action LOXL2 protein-inhibitors; Protein-lysine 6-oxidase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Preclinical Cancer; Hepatic fibrosis; Pulmonary fibrosis; Renal fibrosis
  • Research Non-alcoholic steatohepatitis

Most Recent Events

  • 06 Sep 2017 Pharmacodynamics data from preclinical studies in Pulmonary, Hepatic and Cardiac fibrosis released by Synairgen
  • 06 Sep 2017 Synairgen in collaboration with Pharmaxis plans a phase I trial of a LOXL2 inhibitor for Pulmonary fibrosis in Q4 2017
  • 10 Mar 2017 Pharmacodynamics data from a preclinical trial in Pulmonary fibrosis released by Synairgen
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