LY 3023414

Drug Profile

LY 3023414

Alternative Names: LY3023414

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Eli Lilly; Sarah Cannon Research Institute
  • Developer Eli Lilly; Memorial Sloan-Kettering Cancer Center
  • Class Antineoplastics; Small molecules
  • Mechanism of Action 1 Phosphatidylinositol 3 kinase inhibitors; DNA activated protein kinase inhibitors; MTOR protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Endometrial cancer; Non-small cell lung cancer; Pancreatic cancer; Prostate cancer
  • Phase I Solid tumours

Most Recent Events

  • 10 Jul 2017 The National Cancer Institute plans the phase II Pediatric MATCH trial for Solid tumours, Non-Hodgkin lymphoma, Histiocytosis (with TSC or PI3K/MTOR mutations, Second-line therapy or greater, Metastatic disease, In infants, In children, In adolescents, In adults) In USA (PO) (NCT03213678)
  • 02 Jun 2017 Preliminary safety and efficacy data from a phase I trial in Breast cancer presented at the 53rd Annual Meeting of the American Society of Clinical Oncology
  • 01 Jan 2017 Phase-II clinical trials in Pancreatic cancer (Combination therapy, Metastatic disease, Second-line therapy or greater) in Taiwan, Brazil, Australia, USA (PO) (NCT02981342)
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