LY 3023414

Drug Profile

LY 3023414

Alternative Names: LY3023414

Latest Information Update: 02 Nov 2017

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At a glance

  • Originator Eli Lilly; Sarah Cannon Research Institute
  • Developer Eli Lilly; Memorial Sloan-Kettering Cancer Center
  • Class Antineoplastics; Small molecules
  • Mechanism of Action 1 Phosphatidylinositol 3 kinase inhibitors; DNA activated protein kinase inhibitors; MTOR protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Endometrial cancer; Non-small cell lung cancer; Pancreatic cancer; Prostate cancer
  • Phase I Solid tumours

Most Recent Events

  • 29 Oct 2017 Pharmacodynamics data from a preclinical study in Cancer presented at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics 2017 (AACR-NCI-EORTC-2017)
  • 08 Sep 2017 Interim efficacy and adverse events data from the phase I KEYNOTE238 trial in Non small cell lung cancer (Combination therapy, Late-stage disease) were presented at the 42nd European Society for Medical Oncology Congress
  • 10 Jul 2017 The National Cancer Institute plans the phase II Pediatric MATCH trial for Solid tumours, Non-Hodgkin lymphoma, Histiocytosis (with TSC or PI3K/MTOR mutations, Second-line therapy or greater, Metastatic disease, In infants, In children, In adolescents, In adults) In USA (PO) (NCT03213678)
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