Drug Profile


Alternative Names: EPZ-5676

Latest Information Update: 09 Feb 2017

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At a glance

  • Originator Epizyme
  • Class Antineoplastics; Benzimidazoles; Cyclobutanes; Furans; Purines; Small molecules
  • Mechanism of Action DOT1L protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Leukaemia; Acute lymphoblastic leukaemia; Acute myeloid leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Leukaemia

Most Recent Events

  • 31 Oct 2016 Epizyme establishes CRADA with National Cancer Institute (USA) for the development of pinometostat in Acute leukaemias
  • 31 Oct 2016 Epizyme and National Cancer Institute (USA) plan a clinical trial for Acute leukaemia in USA
  • 01 Jun 2016 Epizyme completes phase-I clinical trials in Leukaemia (In adolescents, In children, In infants) in USA and Canada (IV) (NCT02141828)
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