Brontictuzumab

Drug Profile

Brontictuzumab

Alternative Names: Anti-Notch 1; Anti-Notch 1 monoclonal antibody; OMP-52M51

Latest Information Update: 30 Jan 2017

Price : $50

At a glance

  • Originator OncoMed Pharmaceuticals
  • Developer OncoMed Pharmaceuticals; University of Texas M. D. Anderson Cancer Center
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action Immunomodulators; Notch-1 receptor antagonists; Stem cell inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Colorectal cancer; Solid tumours
  • Clinical Phase Unknown Adenocarcinoma
  • Discontinued Haematological malignancies

Most Recent Events

  • 20 Jan 2017 Phase-I clinical trials in Colorectal cancer (Combination therapy, Metastatic disease, Second-line therapy or greater) in USA (IV) (NCT03031691)
  • 03 Dec 2016 Additional safety and efficacy data from a phase Ia trial in Solid tumours (Treatment-resistant, Second-line therapy or greater) presented at the 58th Annual Meeting and Exposition of the American Society of Hematology (ASH-2016)
  • 22 Jul 2016 Phase-I development is ongoing for Solid tumours in USA (NCT01778439; OncoMed Pharmaceuticals pipeline, July 2016)
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