Drug Profile


Alternative Names: JNJ-42756493; JNJ-493

Latest Information Update: 02 Dec 2016

Price : $50

At a glance

  • Originator Astex Therapeutics
  • Developer Janssen Research & Development
  • Class Antineoplastics; Diamines; Pyrazoles; Quinoxalines; Small molecules
  • Mechanism of Action Fibroblast growth factor receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Cholangiocarcinoma; Gastric cancer; Non-small cell lung cancer; Oesophageal cancer; Urogenital cancer
  • Phase I/II Hepatocellular carcinoma; Lymphoma; Solid tumours
  • Phase I Cancer
  • Preclinical Multiple myeloma

Most Recent Events

  • 31 Oct 2016 Preclinical trials in Multiple myeloma in Belgium (PO) before October 2016
  • 31 Oct 2016 University Health Network, Toronto plans a phase II trial for Multiple myeloma (Combination therapy, Second-line therapy or greater) in Canada (PO) (NCT02952573)
  • 07 Oct 2016 Safety, pharmacokinetics, pharmacodynamics and efficacy data from a phase I trial in Solid tumours presented at the 41st European Society for Medical Oncology Congress (ESMO-2016) (3210958; 3211642)
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