Erdafitinib

Drug Profile

Erdafitinib

Alternative Names: G-024; JNJ-42756493; JNJ-493

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Astex Therapeutics
  • Developer Genentech; Janssen Research & Development; Multiple Myeloma Research Consortium; National Cancer Institute (USA); University Health Network of Toronto; Vanderbilt-Ingram Cancer Center
  • Class Antineoplastics; Diamines; Pyrazoles; Quinoxalines; Small molecules
  • Mechanism of Action Fibroblast growth factor receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Cholangiocarcinoma; Gastric cancer; Multiple myeloma; Non-small cell lung cancer; Oesophageal cancer; Urogenital cancer
  • Phase I/II Hepatocellular carcinoma; Lymphoma; Solid tumours
  • Phase I Breast cancer; Cancer

Most Recent Events

  • 11 Aug 2017 Vanderbilt-Ingram Cancer Center plans a phase I trial for Breast cancer (Metastatic disease) in USA (NCT03238196)
  • 10 Aug 2017 Phase-I clinical trials in Breast cancer (Metastatic disease) in USA (PO) (NCT03238196)
  • 06 Jul 2017 National Cancer Institute plans a phase II Pediatric MATCH trial for Solid tumours and Non-Hodgkin lymphoma (Late-stage disease, Second-line therapy or greater) in USA (PO) (NCT03210714)
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