Drug Profile


Alternative Names: XAF-5; XOPH5

Latest Information Update: 14 Jul 2017

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At a glance

  • Originator Harvard Medical School
  • Developer Allergan
  • Class Small molecules
  • Mechanism of Action Adipocyte inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II/III Subcutaneous fat disorders

Most Recent Events

  • 21 Apr 2016 Topokine Therapeutics has been acquired and merged into Allergan
  • 26 Feb 2016 Topokine Therapeutics suspends enrolment in a phase IIa trial for Subcutaneous fat disorders (excess submental fat) in USA (NCT01990326)
  • 01 Jan 2016 Phase-II/III clinical trials in Subcutaneous fat disorders (lower lid steatoblepharon in adults and the elderly) in USA (Topical, ointment) (NCT02607683)
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