Durvalumab- MedImmune

Drug Profile

Durvalumab- MedImmune

Alternative Names: Anti-PD-L1 monoclonal antibody; Anti-PD-LI mAb; Anti-programmed cell death 1 ligand 1 monoclonal antibody; Imfinzi; MEDI-4736

Latest Information Update: 12 Oct 2017

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At a glance

  • Originator MedImmune
  • Developer Advaxis; AstraZeneca; Canadian Cancer Trials Group; Case Comprehensive Cancer Center; Celgene International SARL; Centre Leon Berard; Childrens Hospital Los Angeles; Eli Lilly; Fondazione IRCCS Istituto Nazionale dei Tumori; GlaxoSmithKline; Gradalis; Grand Hopital de Charleroi; Grupo Espanol de Tumores Neuroendocrinos; Gustave Roussy; Immunocore; Institut Claudius Regaud; Juno Therapeutics; Kyoto Breast Cancer Research Network; Ludwig Institute for Cancer Research; M. D. Anderson Cancer Center; MedImmune; Memorial Sloan-Kettering Cancer Center; Mirati Therapeutics; National Cancer Institute (USA); National Health and Medical Research Council; Northwestern University; Pharmacyclics; Plexxikon; Samsung Medical Center; Seoul National University Hospital; Swiss Group for Clinical Cancer Research; University of Maryland Greenbaum Cancer Center; University of Texas M. D. Anderson Cancer Center; VentiRx Pharmaceuticals; Washington University School of Medicine; Yale University
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action CD274 antigen inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Urogenital cancer
  • Phase III Head and neck cancer; Non-small cell lung cancer; Small cell lung cancer; Solid tumours
  • Phase II/III Breast cancer; Pancreatic cancer
  • Phase II Acute myeloid leukaemia; Biliary cancer; Brain metastases; Colorectal cancer; Diffuse large B cell lymphoma; Endometrial cancer; Fallopian tube cancer; Gastric cancer; Glioblastoma; Hepatocellular carcinoma; Mesothelioma; Multiple myeloma; Myelodysplastic syndromes; Neuroendocrine tumours; Oesophageal cancer; Ovarian cancer; Peritoneal cancer; Prostate cancer; Sarcoma
  • Phase I/II Cervical cancer; Chronic lymphocytic leukaemia; Cutaneous T cell lymphoma; Lung cancer; Lymphoma; Malignant melanoma; Peripheral T-cell lymphoma; Soft tissue sarcoma
  • Phase I CNS cancer; Lymphoproliferative disorders; Myelofibrosis; Non-Hodgkin's lymphoma; Oropharyngeal cancer; Renal cell carcinoma; Thyroid cancer

Most Recent Events

  • 09 Oct 2017 AstraZeneca plans the HIMALAYA phase III trial for Hepatocellular carcinoma (First-line treatment, Unresectable/Inoperable) in Brazil, Canada, France, Germany, Hong Kong, India, Italy, Japan, Russia, South Korea, Thailand, Ukraine, USA and Vietnam (NCT03298451)
  • 03 Oct 2017 MedImmune and Northwestern University suspends patient enrolment in a phase II trial for Breast cancer (Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (IV) (NCT02536794)
  • 28 Sep 2017 Celgene and Memorial Sloan Kettering Cancer Center terminates a phase-I trial in Lymphoproliferative disorders in USA as per the FDA recommendation (IV), before September 2017 (NCT03196401)
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