AMG 232

Drug Profile

AMG 232

Alternative Names: AMG-232

Latest Information Update: 15 May 2017

Price : $50

At a glance

  • Originator Amgen
  • Developer Amgen; GlaxoSmithKline; National Cancer Institute (USA); Vanderbilt University Medical Center
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Proto-oncogene protein c mdm2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Malignant melanoma
  • Phase I Acute myeloid leukaemia; Glioblastoma; Multiple myeloma; Solid tumours
  • Preclinical Adenocarcinoma

Most Recent Events

  • 13 Apr 2017 Phase-I clinical trials in Glioblastoma (Newly diagnosed, First-line therapy) in USA (PO) (NCT03107780)
  • 13 Apr 2017 Phase-I clinical trials in Glioblastoma (Recurrent, Second-line therapy or greater) in USA (PO) (NCT03107780)
  • 01 Apr 2017 Pharmacodynamics data from preclinical trials in Adenocarcinoma presented at the 108th Annual Meeting of the American Association for Cancer Research (AACR-2017)
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