Drug Profile


Alternative Names: CC-220; Iberdomide hydrochloride

Latest Information Update: 04 Nov 2017

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At a glance

  • Originator Celgene Corporation
  • Class Anti-inflammatories; Antineoplastics; Isoindoles; Piperidones; Skin disorder therapies; Small molecules
  • Mechanism of Action CRBN protein inhibitors; Immunomodulators; Transcription factor modulators; Ubiquitin protein ligase complex modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Systemic lupus erythematosus
  • Phase I/II Multiple myeloma
  • Discontinued Cutaneous lupus erythematosus; Haematological malignancies; Sarcoidosis; Systemic scleroderma

Most Recent Events

  • 16 Oct 2017 Celgene completes a phase I trial in Healthy volunteers in USA (NCT03294603)
  • 11 Sep 2017 Celgene initiates enrolment in a phase I trial in Healthy volunteers in USA (NCT03294603)
  • 06 Jul 2017 Phase-II clinical trials in Systemic lupus erythematosus in Hungary, Spain (PO) (EudraCT2016-004574-17) (NCT03161483)
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