Drug Profile


Alternative Names: AZD3293; BACE inhibitor - AstraZeneca; Beta secretase inhibitor - AstraZeneca; LY 3314814

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Astex Pharmaceuticals; AstraZeneca
  • Developer AstraZeneca; Eli Lilly
  • Class Antidementias; Imidazoles; Pyridines; Small molecules; Spiro compounds
  • Mechanism of Action Amyloid precursor protein secretase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Alzheimer's disease

Most Recent Events

  • 24 Jul 2017 Eli Lilly plans a phase I trial in Healthy volunteers in United Kingdom (NCT03222427)
  • 10 Jul 2017 AstraZeneca announces intention to submit regulatory applications for Alzheimer's disease in USA, European Union and Japan in 2020 (AstraZeneca pipeline, July 2017)
  • 22 May 2017 Eli Lilly and AstraZeneca completes a phase I drug-interaction trial in Healthy volunteers in USA (PO) (NCT03019549)
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