Drug Profile


Alternative Names: RG-7221; RO-5520985

Latest Information Update: 14 Oct 2017

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At a glance

  • Originator Roche
  • Class Antineoplastics; Bispecific antibodies; Monoclonal antibodies
  • Mechanism of Action Angiopoietin-2 inhibitors; Vascular endothelial growth factor A inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Colorectal cancer
  • Phase I Solid tumours

Most Recent Events

  • 08 Oct 2017 Adverse events and efficacy data from a phase I trial in Solid tumours released by Roche
  • 03 Jun 2017 Final efficacy and adverse events data from a phase II McCAVE trial in Colorectal cancer (Combination therapy, First-line therapy, Metastatic disease) presented at the 53rd annual meeting of the American Society of Clinical Oncology (ASCO-2017)
  • 01 Feb 2017 Roche completes a phase II trial in Colorectal cancer (Combination therapy, First-line therapy, Metastatic disease) in USA, Australia, France, Spain, Austria, Italy, Belgium and United Kingdom (IV) (NCT02141295)
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