NGM 282

Drug Profile

NGM 282

Alternative Names: NGM-282

Latest Information Update: 03 Oct 2017

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At a glance

  • Originator NGM Biopharmaceuticals
  • Class Antihyperglycaemics
  • Mechanism of Action Cholesterol 7 alpha hydroxylase inhibitors; Fibroblast growth factor receptor modulators; Type 1 fibroblast growth factor receptor modulators; Type 4 fibroblast growth factor receptor modulators; Type-2 fibroblast growth factor receptor modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Primary biliary cirrhosis
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Non-alcoholic steatohepatitis; Primary biliary cirrhosis; Primary sclerosing cholangitis; Type 2 diabetes mellitus
  • Phase I/II Constipation

Most Recent Events

  • 01 Jun 2017 NGM Biopharmaceuticals completes a phase II trial in Primary sclerosing cholangitis in USA, United Kingdom, Netherlands, France (SC) (NCT02704364)
  • 06 May 2017 Safety and efficacy data from a phase Ib/II trial in Constipation presented at the Digestive Disease Week (DDW-2017)
  • 22 Apr 2017 Safety and efficacy data from a phase II clinical trial in Non-alcoholic steatohepatitis released by NGM Biopharmaceuticals
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