Sacituzumab govitecan - Immunomedics

Drug Profile

Sacituzumab govitecan - Immunomedics

Alternative Names: hRS7-SN38 antibody drug conjugate; IMMU-132; Isactuzumab govitecan; TROP-2-SN-38

Latest Information Update: 08 Dec 2017

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At a glance

  • Originator IBC Pharmaceuticals; Immunomedics
  • Developer Immunomedics
  • Class Antineoplastics; Camptothecins; Drug conjugates; Immunoconjugates; Monoclonal antibodies
  • Mechanism of Action DNA topoisomerase I inhibitors; Immunomodulators; TROP2 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Small cell lung cancer; Pancreatic cancer
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase III Breast cancer
  • Phase II Solid tumours
  • Preclinical Pancreatic cancer; Small cell lung cancer

Most Recent Events

  • 06 Dec 2017 Efficacy data from a phase II trial in Breast cancer released by Immunomedics
  • 12 Oct 2017 Phase-III clinical trials in Breast cancer (Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (IV) (NCT02574455)
  • 11 Sep 2017 Updated interim efficacy and adverse events data from a phase II trial in Solid tumours presented at the European Society for Medical Oncology (ESMO-2017) Congress
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