Avelumab

Drug Profile

Avelumab

Alternative Names: Anti-PD-L1 monoclonal antibody - EMD Serono; Anti-PD-L1 monoclonal antibody - Merck; MSB-0010718C; PF-06834635

Latest Information Update: 17 Mar 2017

Price : $50

At a glance

  • Originator EMD Serono; Merck KGaA
  • Developer EMD Serono; Hospices Civils de Lyon; Merck KGaA; National Cancer Institute (USA); Pfizer; Syndax Pharmaceuticals; Vanderbilt-Ingram Cancer Center; Verastem
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action CD274 antigen inhibitors; Immunomodulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Merkel cell carcinoma
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

    Merkel cell carcinoma
  • New Molecular Entity Yes

Highest Development Phases

  • Preregistration Merkel cell carcinoma; Urogenital cancer
  • Phase III Breast cancer; Diffuse large B cell lymphoma; Gastric cancer; Head and neck cancer; Non-small cell lung cancer; Ovarian cancer; Renal cell carcinoma
  • Phase II Endometrial cancer; Gestational trophoblastic disease; Glioblastoma; Intestinal cancer; Nasopharyngeal cancer; Recurrent respiratory papillomatosis; Thymoma
  • Phase I/II Fallopian tube cancer; Peritoneal cancer
  • Phase I Acute myeloid leukaemia; Hodgkin's disease; Solid tumours
  • Phase Unknown Peripheral T-cell lymphoma

Most Recent Events

  • 10 Mar 2017 Fred Hutchinson Cancer Research Center and National Cancer Institute plan a phase I/II trial for Leiomyosarcoma and Liposarcoma (Metastatic disease, Combination therapy, Late-stage disease) in USA (NCT03074318)
  • 06 Mar 2017 Phase-II clinical trials in Thymoma (Second-line therapy or greater, Recurrent, Late-stage disease, Refractory metastatic disease, Inoperable/Unresectable) in USA (IV) (NCT03076554)
  • 03 Mar 2017 Phase-II clinical trials in Intestinal cancer (Metastatic disease, Late-stage disease, Monotherapy) in USA (IV)
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