Avelumab

Drug Profile

Avelumab

Alternative Names: Anti-PD-L1 monoclonal antibody - EMD Serono; Anti-PD-L1 monoclonal antibody - Merck; BAVENCIO; MSB-0010718C; PF-06834635

Latest Information Update: 18 Aug 2017

$50 / €47 *
* $ price applies to USA, Canada and Latin America. € price applies to the rest of the world. Final gross prices may vary according to local VAT.

At a glance

  • Originator EMD Serono; Merck KGaA
  • Developer AIO Studien gGmbH; EMD Serono; Hospices Civils de Lyon; Merck KGaA; National Cancer Institute (USA); Pfizer; Syndax Pharmaceuticals; University of California, San Diego; Vanderbilt-Ingram Cancer Center; Verastem
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action CD274 antigen inhibitors; Immunomodulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Merkel cell carcinoma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Merkel cell carcinoma
  • Registered Urogenital cancer
  • Phase III Breast cancer; Diffuse large B cell lymphoma; Gastric cancer; Head and neck cancer; Non-small cell lung cancer; Ovarian cancer; Renal cell carcinoma
  • Phase II Colorectal cancer; Endometrial cancer; Gestational trophoblastic disease; Glioblastoma; Intestinal cancer; Nasopharyngeal cancer; Recurrent respiratory papillomatosis; Thymoma
  • Phase I/II Fallopian tube cancer; Peritoneal cancer
  • Phase I Acute myeloid leukaemia; Hodgkin's disease; Solid tumours

Most Recent Events

  • 21 Jul 2017 Merck expects a decision on approval for Merkel cell carcinoma (Metastatic disease, Second-line therapy or greater, Monotherapy, In adults) in European Union in the third quarter of 2017
  • 20 Jul 2017 Phase-II clinical trials in Merkel cell carcinoma (Metastatic disease, First-line therapy) (IV) (NCT02155647)
  • 20 Jul 2017 Committee for Medicinal Products for Human Use (CHMP) of EMA adopts a positive opinion recommending approval of avelumab for Merkel cell carcinoma (Second-line therapy or greater, Metastatic disease, Monotherapy, In adults)
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