Avelumab

Drug Profile

Avelumab

Alternative Names: Anti-PD-L1 monoclonal antibody - EMD Serono; Anti-PD-L1 monoclonal antibody - Merck; BAVENCIO; MSB-0010718C; PF-06834635

Latest Information Update: 31 Mar 2017

Price : $50

At a glance

  • Originator EMD Serono; Merck KGaA
  • Developer EMD Serono; Hospices Civils de Lyon; Merck KGaA; National Cancer Institute (USA); Pfizer; Syndax Pharmaceuticals; University of California, San Diego; Vanderbilt-Ingram Cancer Center; Verastem
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action CD274 antigen inhibitors; Immunomodulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Merkel cell carcinoma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Merkel cell carcinoma
  • Preregistration Urogenital cancer
  • Phase III Breast cancer; Diffuse large B cell lymphoma; Gastric cancer; Head and neck cancer; Non-small cell lung cancer; Ovarian cancer; Renal cell carcinoma
  • Phase II Endometrial cancer; Gestational trophoblastic disease; Glioblastoma; Intestinal cancer; Nasopharyngeal cancer; Recurrent respiratory papillomatosis; Thymoma
  • Phase I/II Fallopian tube cancer; Peritoneal cancer
  • Phase I Acute myeloid leukaemia; Hodgkin's disease; Solid tumours

Most Recent Events

  • 31 Mar 2017 Merck initiates an expanded access to avelumab for Merkel cell carcinoma (Metastatic disease, Second-line therapy) in France (NCT03089658)
  • 29 Mar 2017 Avelumab is still in phase I trials for Solid tumours in USA, Belgium, Czech Republic, France, Germany, Hungary, South Korea, Poland, Taiwan and United Kingdom (NCT01772004)
  • 24 Mar 2017 Launched for Merkel cell carcinoma (Metastatic disease, Second-line therapy or greater, In adults, In adolescents) in USA (IV) - First global launch
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