Research programme: cancer therapeutics - Syros Pharmaceuticals

Drug Profile

Research programme: cancer therapeutics - Syros Pharmaceuticals

Alternative Names: CDK12/12 inhibitors - Syros Pharmaceuticals; Cyclin-dependent kinase 12/13 inhibitors - Syros Pharmaceuticals; Cyclin-dependent kinase 7 inhibitors; SY 351; SY-1365; THZ1; THZ531

Latest Information Update: 25 Mar 2017

Price : $50

At a glance

  • Originator Syros Pharmaceuticals
  • Developer Dana-Farber Cancer Institute; Syros Pharmaceuticals; Whitehead Institute for Biomedical Research
  • Class Small molecules
  • Mechanism of Action Cyclin-dependent kinase inhibitors; Cyclin-dependent kinase-activating kinase inhibitors; Gene expression modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

    No
  • New Molecular Entity No

Highest Development Phases

  • Preclinical Acute lymphoblastic leukaemia; Acute myeloid leukaemia; Breast cancer; Cancer; Ewing's sarcoma; Neuroblastoma; Small cell lung cancer

Most Recent Events

  • 24 Mar 2017 Preclinical trials in Cancer in USA (unspecified route) for CDK12/13 inhibitor
  • 20 Mar 2017 Syros Pharmaceuticals plans a phase I trial of SY 1365 in Acute leukaemia and Solid tumours the second quarter of 2017
  • 14 Nov 2016 Syros Pharmaceuticals plans a phase I trial for solid tumours, including triple-negative breast cancer, ovarian cancer and small cell lung cancer in ,
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