M 6620

Drug Profile

M 6620

Alternative Names: Captisol® enabled VX 970; M6620; VX-970

Latest Information Update: 11 Oct 2017

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At a glance

  • Originator Vertex Pharmaceuticals
  • Developer Merck KGaA; National Cancer Institute (USA)
  • Class Antineoplastics
  • Mechanism of Action ATR protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Fallopian tube cancer; Ovarian cancer; Peritoneal cancer; Urogenital cancer
  • Phase I/II Small cell lung cancer; Solid tumours
  • Phase I Breast cancer; Non-small cell lung cancer
  • Preclinical Acute myeloid leukaemia

Most Recent Events

  • 13 Oct 2017 Merck KGaA plans a rollover phase I trial for Solid tumours (Late-stage disease, Monotherapy, Combination therapy) in Germany (IV) (NCT03309150)
  • 08 Sep 2017 Initial efficacy and adverse events data from a phase I trial in Breast cancer presented at the 42nd European Society for Medical Oncology Congress (ESMO-2017)
  • 11 Jan 2017 VX 970 licensed to Merck KGaA worldwide
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