Drug Profile


Alternative Names: GS 5745; MMP9 mAb inhibitor - Gilead

Latest Information Update: 20 May 2017

Price : $50

At a glance

  • Originator Gilead Sciences
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action Matrix metalloproteinase 9 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Gastric cancer
  • Phase II/III Ulcerative colitis
  • Phase II Crohn's disease; Cystic fibrosis; Rheumatoid arthritis
  • Phase I Chronic obstructive pulmonary disease; Solid tumours

Most Recent Events

  • 07 Mar 2017 GS 5745 is now called andecaliximab (NCT01803282)
  • 27 Feb 2017 Andecaliximab is still in phase I trials for Solid tumours in USA (Gilead Sciences 10-K, February 2017)
  • 01 Dec 2016 Gilead Sciences completes A Phase II trial in Crohn's disease in US, Australia, Canada, New Zealand, Hungary, Germany, Czech Republic, Spain, the UK, France, Italy, Iceland, Poland and South Africa (EudraCT2015-001249-10; NCT02405442)
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