Drug Profile


Alternative Names: GS 5745; MMP9 mAb inhibitor - Gilead

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Gilead Sciences
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action Matrix metalloproteinase 9 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Gastric cancer
  • Phase I Solid tumours
  • Discontinued Chronic obstructive pulmonary disease; Crohn's disease; Cystic fibrosis; Rheumatoid arthritis; Ulcerative colitis

Most Recent Events

  • 31 Aug 2017 Discontinued - Phase-I for Chronic obstructive pulmonary disease in USA (IV)
  • 31 Aug 2017 Discontinued - Phase-I for Ulcerative colitis (In volunteers) in New Zealand (IV) (SC)
  • 31 Aug 2017 Discontinued - Phase-I for Ulcerative colitis in Romania, Netherlands, Moldova, Hungary, USA, Canada, Belgium (IV)
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