Anlotinib

Drug Profile

Anlotinib

Alternative Names: AL 3818; ALTN; Anlotinib hydrochloride

Latest Information Update: 22 Mar 2017

Price : $50

At a glance

  • Originator Advenchen Laboratories; Jiangsu Chia-Tai Tianqing Pharmaceutical
  • Developer Advenchen Laboratories; Chia Tai Tianqing Pharmaceutical Group
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Fibroblast growth factor receptor antagonists; Platelet-derived growth factor beta receptor antagonists; Proto oncogene protein c-kit inhibitors; Vascular endothelial growth factor receptor 3 antagonists; Vascular endothelial growth factor receptor antagonists; Vascular endothelial growth factor receptor-2 antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Colorectal cancer; Gastric cancer; Non-small cell lung cancer; Thyroid cancer
  • Phase II Hepatocellular carcinoma; Oesophageal cancer; Renal cell carcinoma; Small cell lung cancer; Soft tissue sarcoma
  • Phase I/II Cervical cancer; Endometrial cancer; Fallopian tube cancer; Ovarian cancer; Peritoneal cancer
  • Phase Unknown Alveolar soft part sarcoma; Leiomyosarcoma; Synovial sarcoma

Most Recent Events

  • 01 Mar 2017 Phase-II clinical trials in Small cell lung cancer (Late-stage disease, Second-line therapy or greater) in China (PO) (NCT03059797)
  • 26 Feb 2017 Jiangsu Chia-tai Tianqing Pharmaceutical plans the ALTER1202 phase II trial for Small cell lung cancer (Second-line therapy or greater) in China (NCT03059797)
  • 09 Jan 2017 Advenchen Laboratories plans the phase III APROMISS trial for Alveolar soft part sarcoma (Inoperable/Unresectable, Metastatic disease, Late-stage disease), Leiomyosarcoma and Synovial-sarcoma (Recurrent, Inoperable/Unresectable, Metastatic disease, Late-stage disease, Second-line therapy or greater) in USA (PO) (NCT03016819)
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