Drug Profile


Alternative Names: AL 8176; ALS 008176; ALS-8176; JNJ-1575; JNJ-64041575

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Alios BioPharma
  • Developer Alios BioPharma; Janssen Research & Development
  • Class Antivirals; Furans; Nucleosides; Pyrimidines
  • Mechanism of Action RNA replicase inhibitors; Virus replication inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Respiratory syncytial virus infections
  • Preclinical Metapneumovirus infections; Parainfluenza virus infections

Most Recent Events

  • 28 Jun 2017 Janssen initiates enrolment in a phase I pharmacokinetic trial in Germany (NCT03189498)
  • 21 Jun 2017 Janssen plans a pharmacokinetic phase I trial in Germany (NCT03189498)
  • 16 Jun 2017 Janssen completes a phase I trial in Respiratory syncytial virus infections (In volunteers) in Germany (NCT03105986)
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