Decitabine/E 7727 - Astex

Drug Profile

Decitabine/E 7727 - Astex

Alternative Names: ASTX 727; Decitabine/E7727; E-7727/decitabine

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Astex Pharmaceuticals
  • Class Antineoplastics; Aza compounds; Deoxyribonucleosides; Pyrimidine nucleosides; Ribonucleosides; Small molecules
  • Mechanism of Action Cytidine deaminase inhibitors; DNA methylation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Chronic myelomonocytic leukaemia; Myelodysplastic syndromes

Most Recent Events

  • 22 Jun 2017 Phase-II clinical trials in Chronic myelomonocytic leukaemia in USA before June 2017 (PO)
  • 22 Jun 2017 Phase-II clinical trials in Myelodysplastic syndromes in USA before June 2017 (PO)
  • 22 Jun 2017 Efficacy and adverse events data from a phase II trial in Chronic myelomonocytic leukaemia and Myelodysplastic syndromes presented at the 22nd Congress of the European Haematology Association (EHA-2017)
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