Decitabine/E 7727 - Astex

Drug Profile

Decitabine/E 7727 - Astex

Alternative Names: ASTX 727; Decitabine/E7727; E-7727/decitabine

Latest Information Update: 20 May 2017

Price : $50

At a glance

  • Originator Astex Pharmaceuticals
  • Class Antineoplastics; Aza compounds; Deoxyribonucleosides; Pyrimidine nucleosides; Ribonucleosides; Small molecules
  • Mechanism of Action Cytidine deaminase inhibitors; DNA methylation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Myelodysplastic syndromes

Most Recent Events

  • 03 Dec 2016 Efficacy, adverse events and pharmacokinetics data from a phase I/II trial in Myelodysplastic syndromes presented at the 58th Annual Meeting and Exposition of the American Society of Haematology (ASH-Hem-2016)
  • 25 May 2016 Phase I/II development is ongoing in USA
  • 25 May 2016 Phase-I/II clinical trials in Myelodysplastic syndromes in Canada (PO) (NCT02103478)
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