Vadastuximab talirine

Drug Profile

Vadastuximab talirine

Alternative Names: 33 A; Anti-CD33A targeted ADC - Seattle Genetics; SGN CD33A

Latest Information Update: 06 Jan 2017

Price : $50

At a glance

  • Originator Seattle Genetics
  • Class Antineoplastics; Benzodiazepines; Drug conjugates; Immunoconjugates; Immunotoxins; Monoclonal antibodies; Pyrroles
  • Mechanism of Action CD33 antigen inhibitors; Cytoadhesin receptor antagonists; DNA cross linking agents
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia
  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Acute myeloid leukaemia
  • Phase I/II Myelodysplastic syndromes

Most Recent Events

  • 27 Dec 2016 Suspended - Phase-I for Acute myeloid leukaemia in USA due to partial clinical hold (IV) (NCT01902329) (NCT02326584)
  • 27 Dec 2016 Suspended - Phase-I/II for Acute myeloid leukaemia (Combination therapy, Monotherapy, Second-line therapy or greater) in USA due to full clinical hold (IV) (NCT02614560)
  • 05 Dec 2016 Updated efficacy and adverse events data from two phase I trials in Acute myeloid leukaemia presented at the 58th American Society of Hematology Annual Meeting and Exposition (ASH-2016)
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