Drug Profile


Alternative Names: Anti-plasma kallikrein mAb; Anti-plasma kallikrein monoclonal antibody; DX-2930; SHP 643

Latest Information Update: 20 May 2017

Price : $50

At a glance

  • Originator Dyax
  • Developer Shire
  • Class Monoclonal antibodies; Skin disorder therapies
  • Mechanism of Action Plasma-kallikrein-inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hereditary angioedema
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Hereditary angioedema
  • Preclinical Diabetic macular oedema

Most Recent Events

  • 21 Feb 2017 Shire announces intention to submit BLA to US FDA for Hereditary angioedema in 2017 (Shire pipeline, February 2017)
  • 01 Nov 2016 Shire completes enrolment in the phase III HELP study in Hereditary angioedema in USA, Jordan, Germany, Puerto Rico, Canada, Italy and United Kingdom
  • 01 May 2016 Phase-III clinical trials in Hereditary angioedema (In adolescents, Prevention, In adults) in Canada, Italy, Germany, Jordan, United Kingdom (SC) (NCT02741596)
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