Enasidenib

Drug Profile

Enasidenib

Alternative Names: AG 221 mesylate; AG-221; AGI 12910 mesylate; AGI-12910; CC-90007; IDHIFA

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Agios Pharmaceuticals
  • Developer Agios Pharmaceuticals; Celgene Corporation
  • Class Antineoplastics; Propanols; Pyridines; Small molecules; Triazines
  • Mechanism of Action Isocitrate dehydrogenase 2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Registered Acute myeloid leukaemia
  • Phase I/II Myelodysplastic syndromes; Solid tumours

Most Recent Events

  • 26 Sep 2017 Celgene plans a phase I pharmacokinetic trial (NCT03290443)
  • 01 Aug 2017 Registered for Acute myeloid leukaemia (In the elderly, In adults, Late-stage disease, Second-line therapy or greater) in USA (PO) - First global approval
  • 01 Aug 2017 Updated efficacy and adverse events data from a phase I/II trial in Acute myeloid leukaemia released by Celgene Corporation and Agios Pharmaceuticals
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