Drug Profile


Alternative Names: 14-O-phosphonooxymethyltriptolide-disodium-salt; Minnelide; Minnelide-001

Latest Information Update: 25 Apr 2017

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At a glance

  • Originator University of Minnesota
  • Developer Barts and The London NHS Trust; Minneamrita Therapeutics; Queen Mary University of London; Translational Genomics Research Institute
  • Class Antineoplastics; Diterpenes; Epoxy compounds; Phenanthrenes; Phosphoric acid esters
  • Mechanism of Action HSP70 heat shock protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity No

Highest Development Phases

  • Phase II Pancreatic cancer
  • Phase I Gastrointestinal cancer

Most Recent Events

  • 28 Apr 2017 Minneamrita Therapeutics plans a phase I trial for Solid tumours (Late-stage disease, Metastatic disease, Monotherapy, Combination therapy) in USA (NCT03129139)
  • 10 Apr 2017 Phase-II clinical trials in Pancreatic cancer (Metastatic disease, Second-line therapy or greater) in USA (IV) (NCT03117920)
  • 15 Mar 2016 Biomarkers information updated
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