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Afabicin - Debiopharm

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Drug Profile

Afabicin - Debiopharm

Alternative Names: AFN 1720; AFN-1252-prodrug; Debio 1450; Debio-1452-prodrug

Latest Information Update: 28 May 2025

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At a glance

  • Originator Affinium Pharmaceuticals
  • Developer Debiopharm Group
  • Class Anti-infectives; Benzofurans; Naphthyridines; Small molecules
  • Mechanism of Action Enoyl ACP reductase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Bone and joint infections; Osteomyelitis
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Bone and joint infections; Skin and soft tissue infections
  • No development reported Staphylococcal infections

Most Recent Events

  • 28 May 2025 No recent reports of development identified for phase-I development in Bone-and-joint-infections in USA (IV, Infusion)
  • 28 May 2025 No recent reports of development identified for phase-I development in Bone-and-joint-infections in USA (PO, Powder)
  • 23 Apr 2025 Debiopharm terminates a phase II trial in Bone and joint infections in Georgia, Ukraine and South Africa (IV) due to strategic reasons (NCT03723551)

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