PLX 7486

Drug Profile

PLX 7486

Alternative Names: PLX-7486; PLX7486-TsOH

Latest Information Update: 18 Apr 2016

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At a glance

  • Originator Plexxikon
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Fms-like tyrosine kinase 3 inhibitors; TrkA receptor antagonists; TrkB receptor antagonists; TrkC receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Pancreatic cancer; Solid tumours

Most Recent Events

  • 18 Apr 2016 Phase I development is ongoing in USA
  • 01 Aug 2013 Phase-I clinical trials in Solid tumours & Pancreatic cancer (late-stage disease, second-line therapy or greater) in USA (PO)
  • 03 Jun 2013 Plexxikon files an IND application with the US FDA for PLX 7486 for Solid tumours
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