Research programme: protein degradation-based therapeutics - Arvinas

Drug Profile

Research programme: protein degradation-based therapeutics - Arvinas

Alternative Names: ARCC-29; ARV-771; BET-PROTAC ARV-771; Hydrophobic Tagging small molecules - Arvinas; HyT small molecules - Arvinas; PROTAC ARV-771; PROTAC ARV-825; PROTACs - Arvinas; Protein-targeting chimeric molecules - Arvinas; Proteolysis Targeting Chimeric molecules - Arvinas

Latest Information Update: 25 Apr 2017

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At a glance

  • Originator Arvinas
  • Developer Arvinas; Yale University
  • Class Small molecules
  • Mechanism of Action BRD4-protein-inhibitors; Bromodomain and extraterminal domain protein inhibitors; Proteasome stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Breast cancer; Haematological malignancies; Prostate cancer; Solid tumours
  • Research Autoimmune disorders; Inflammation

Most Recent Events

  • 20 Sep 2017 Arvinas plans phase I trials for Breast Cancer and Prostate Cancer in USA in 2018
  • 01 Apr 2017 Pharmacodynamics data from two preclinical studies in Cancer presented at the 108th Annual Meeting of the American Association for Cancer Research (AACR-2017)
  • 09 Dec 2016 Preclinical trials in Breast cancer in USA (PO)
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