Research programme: protein degradation-based therapeutics - Arvinas

Drug Profile

Research programme: protein degradation-based therapeutics - Arvinas

Alternative Names: ARV-771; BET-PROTAC ARV-771; Hydrophobic Tagging small molecules - Arvinas; HyT small molecules - Arvinas; PROTAC ARV-771; PROTAC ARV-825; PROTACs - Arvinas; Protein-targeting chimeric molecules - Arvinas; Proteolysis Targeting Chimeric molecules - Arvinas

Latest Information Update: 15 Dec 2016

Price : $50

At a glance

  • Originator Arvinas
  • Developer Arvinas; Yale University
  • Class Small molecules
  • Mechanism of Action Bromodomain and extraterminal domain protein inhibitors; Proteasome stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • On Fast track

    Fast track status is assigned by the US FDA so therapies with the potential to address unmet needs can move faster through development.

  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Haematological malignancies; Solid tumours
  • Research Autoimmune disorders; Inflammation

Most Recent Events

  • 06 Dec 2016 Preclinical data presented at the 58th Annual Meeting and Exposition of the American Society of Haematology (ASH-Hem-2016)
  • 02 Dec 2016 Pharmacodynamics data from in vitro studies in Cancer presented at the 28th EORTC-NCI-AACR Molecular Targets and Cancer Therapeutics Symposium (EORTC-NCI-AACR 2016)
  • 07 Jun 2016 Preclinical trials in Haematological malignancies in USA (unspecified route)
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