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Cerdulatinib - Dermavant Sciences/Alexion AstraZeneca Rare Disease

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Drug Profile

Cerdulatinib - Dermavant Sciences/Alexion AstraZeneca Rare Disease

Alternative Names: ALXN 2075; DMVT 502; Dual-SYK/JAK-inhibitor-Alexion AstraZeneca Rare Disease; PRT-062070; PRT-2070; RVT-502; RVT-502 - Dermavant Sciences

Latest Information Update: 26 Mar 2024

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At a glance

  • Originator Portola Pharmaceuticals
  • Developer Alexion AstraZeneca Rare Disease; Dermavant Sciences; NicOx; Portola Pharmaceuticals
  • Class Anti-inflammatories; Antiallergics; Antineoplastics; Antirheumatics; Cyclopropanes; Eye disorder therapies; Piperazines; Pyrimidines; Skin disorder therapies; Small molecules
  • Mechanism of Action Janus kinase inhibitors; Syk kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Peripheral T-cell lymphoma; Non-Hodgkin's lymphoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Chronic lymphocytic leukaemia; Non-Hodgkin's lymphoma
  • Preclinical Precursor B-cell lymphoblastic leukaemia-lymphoma
  • Discontinued Allergic rhinitis; Atopic dermatitis; Eye disorders; Vitiligo

Most Recent Events

  • 19 Mar 2024 Alexion Pharmaceuticals completes a expanded access programme in Chronic lymphocytic leukemia and Non-hodgkin's lymphoma in March 2024 (NCT04757259)
  • 28 Jun 2022 Discontinued (due to company-wide cost optimization and pipeline reprioritization) - Phase-I for Vitiligo in United Kingdom (Topical)
  • 28 Jun 2022 Discontinued - Phase-I for Atopic dermatitis in United Kingdom (Topical)
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