BMS 986016

Drug Profile

BMS 986016

Alternative Names: Anti-LAG-3; Anti-LAG-3 monoclonal antibody; Anti-LAG-3 monoclonal antibody - Bristol-Myers Squibb; Anti-lymphocyte activation gene 3 monoclonal antibody; BMS-986016; ONO-4482

Latest Information Update: 10 Sep 2017

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At a glance

  • Originator Bristol-Myers Squibb
  • Developer Bristol-Myers Squibb; Ono Pharmaceutical; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action CD223 antigen inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Gastric cancer; Renal cell carcinoma
  • Phase I/II Solid tumours
  • Phase I Chronic lymphocytic leukaemia; Diffuse large B cell lymphoma; Glioblastoma; Hodgkin's disease; Mantle-cell lymphoma; Non-Hodgkin's lymphoma

Most Recent Events

  • 03 Jun 2017 Efficacy and adverse events data from a phase I/IIa trial in Solid tumours, including Melanoma released by Bristol-Myers Squibb
  • 01 Jan 2017 Phase-II clinical trials in Renal cell carcinoma (Combination therapy, Late-stage disease) in USA (IV) (NCT02996110)
  • 16 Dec 2016 Bristol-Myers Squibb plans the phase II FRACTION-RCC trial for Renal cell carcinoma (Combination therapy, Late-stage disease) in USA, Israel, Italy and Canada (IV) (NCT02996110)
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