CB 839

Drug Profile

CB 839

Alternative Names: CB839

Latest Information Update: 04 Sep 2017

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At a glance

  • Originator Calithera Biosciences
  • Developer Calithera Biosciences; National Cancer Institute (USA)
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Glutaminase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Breast cancer; Renal cell carcinoma
  • Phase I/II Colorectal cancer; Malignant melanoma; Non-small cell lung cancer
  • Phase I Haematological malignancies; Leukaemia; Solid tumours

Most Recent Events

  • 07 Aug 2017 Phase-II clinical trials in Renal cell carcinoma (Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in Canada, Europe (PO) (NCT03163667)
  • 07 Aug 2017 Calithera Biosciences initiates enrolment in a phase II trial for Renal cell carcinoma (Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (NCT03163667)
  • 01 Aug 2017 Phase-I/II clinical trials in Colorectal cancer (Metastatic disease, Combination therapy, Late-stage disease, Second-line therapy or greater) in USA (PO) (NCT03263429)
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