Drug Profile


Alternative Names: [14C]Lorlatinib; [14C]PF-06463922; PF-06463922; PF-6463922

Latest Information Update: 21 Sep 2017

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At a glance

  • Originator Pfizer
  • Developer Pfizer; The Childrens Hospital of Philadelphia; Yale University
  • Class Antineoplastics; Aza compounds; Benzoxazines; Nitriles; Pyrazoles; Pyridines; Small molecules
  • Mechanism of Action Anaplastic lymphoma kinase inhibitors; ROS1-protein-inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Non-small cell lung cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Non-small cell lung cancer
  • Preclinical Neuroblastoma

Most Recent Events

  • 25 Aug 2017 Pfizer completes a phase I trial in Healthy volunteers in USA (PO) (NCT03184168)
  • 05 Jul 2017 Pfizer initiates enrolment in a phase I trial in Healthy volunteers in USA (PO) (NCT03184168)
  • 14 Jun 2017 Pfizer plans a phase I trial for Healthy volunteers in USA (NCT03184168)
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