ALT 803

Drug Profile

ALT 803

Alternative Names: ALT-803; IL-15N72D:IL-15RαSu/Fc fusion protein complex

Latest Information Update: 08 Nov 2017

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At a glance

  • Originator Altor BioScience Corporation; NantKwest
  • Developer Altor BioScience Corporation; Masonic Cancer Center; NantCell; NantKwest; University of Minnesota; University of South Carolina
  • Class Antineoplastics; Interleukins; Recombinant fusion proteins
  • Mechanism of Action Interleukin-15 receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II/III Bladder cancer
  • Phase II Acute myeloid leukaemia; Merkel cell carcinoma; Non-small cell lung cancer
  • Phase I/II Colorectal cancer; Haematological malignancies; Multiple myeloma; Non-Hodgkin's lymphoma; Pancreatic cancer
  • Phase I Fallopian tube cancer; HIV infections; Malignant melanoma; Ovarian cancer; Peritoneal cancer
  • Preclinical Bacterial infections

Most Recent Events

  • 08 Nov 2017 ALT 803 is still in phase I trials for Malignant melanoma(Late-stage disease) in USA (NCT01946789)
  • 08 Nov 2017 NantKwest plans the phase I/II QUILT-3.060 trial for Pancreatic cancer (Combination therapy, Second-line therapy or greater) in November 2017 (NCT03329248)
  • 04 Nov 2017 No recent reports of development identified for phase-I development in Malignant-melanoma(Late-stage disease) in USA (IV, Infusion)
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