Research programme: benzopyran-based cancer therapeutics - Novogen

Drug Profile

Research programme: benzopyran-based cancer therapeutics - Novogen

Alternative Names: CS-6; SBP therapeutics - Novogen; Super-benzopyran compounds - Novogen; Trilexium (Trx) analogues - Novogen; Trx-2 - Novogen; TRXE-0025; TRXE-009; TRXE-009-1; TRXE-025

Latest Information Update: 18 May 2017

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At a glance

  • Originator Novogen
  • Developer Novogen; Weill Cornell Medical College
  • Class Benzopyrans; Small molecules
  • Mechanism of Action Cell cycle inhibitors; EIF 2 kinase inhibitors; Electron transport chain complex protein inhibitors; Glucuronidase modulators; JNK mitogen-activated protein kinase modulators; NADH oxidase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Glioblastoma; Malignant melanoma; Neuroblastoma; Ovarian cancer; Prostate cancer
  • Research Brain cancer

Most Recent Events

  • 01 Apr 2017 Pharmacodynamics data from preclinical studies in Solid tumours presented at the 108th Annual Meeting of the American Association for Cancer Research
  • 11 May 2016 Novogen unwinds CanTx joint venture with Yale University
  • 02 May 2016 Novogen intends to file an IND application with the US FDA in USA for Ovarian cancer in August 2016
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