VS 5584

Drug Profile

VS 5584

Alternative Names: SB-2312; SB-2343; VS-5584

Latest Information Update: 11 Jan 2017

Price : $50

At a glance

  • Originator S*BIO
  • Developer Verastem
  • Class Antineoplastics; Morpholines; Purines; Pyrimidines; Small molecules
  • Mechanism of Action 1 Phosphatidylinositol 3 kinase inhibitors; MTORC1 protein inhibitors; MTORC2 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Mesothelioma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Lymphoma; Mesothelioma; Solid tumours

Most Recent Events

  • 01 Dec 2016 Verastem terminates a phase I trial in Solid tumours and Lymphoma (Late-stage disease, Metastatic disease) in USA due to lack of recruitment and the company's decision to de-prioritise VS 5584 development (PO) (NCT01991938)
  • 01 Oct 2015 Verastem terminates a phase I trial in Mesothelioma (Second-line therapy or greater, Combination therapy) in USA and United Kingdom (PO) (NCT02372227)
  • 12 Feb 2015 VS 5584 receives Orphan Drug status for Mesothelioma in USA
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