GDC 0853

Drug Profile

GDC 0853

Alternative Names: Bruton’s tyrosine kinase inhibitor - Genentech; GDC-0853; RG 7845; RO 7010939

Latest Information Update: 06 Oct 2017

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At a glance

  • Originator Genentech
  • Class Antineoplastics; Antirheumatics
  • Mechanism of Action Agammaglobulinaemia tyrosine kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Rheumatoid arthritis; Systemic lupus erythematosus; Urticaria
  • Phase I Autoimmune disorders
  • Discontinued Chronic lymphocytic leukaemia; Non-Hodgkin's lymphoma

Most Recent Events

  • 13 Sep 2017 Genentech initiates enrolment in a phase I trial in Healthy volunteers in United Kingdom (NCT03290703)
  • 22 Aug 2017 Roche completes a phase I trial in Healthy volunteers in USA (NCT03188783)
  • 23 Jun 2017 Genentech completes a phase I trial in Healthy volunteers in USA (NCT03174041)
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