EC 1456

Drug Profile

EC 1456

Alternative Names: EC-1456; Folate-targeted tubulysin - Endocyte; Folate-tubulysin; Folic acid-tubulysin conjugate (EC1456) - Endocyte

Latest Information Update: 04 Nov 2017

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At a glance

  • Originator Endocyte
  • Class Antineoplastics; Biological toxins; Peptides; Small molecules
  • Mechanism of Action Folate receptor 1 antagonists; Mitosis inhibitors; Tubulin inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Non-small cell lung cancer; Ovarian cancer
  • Preclinical Breast cancer; Endometrial cancer
  • No development reported Solid tumours

Most Recent Events

  • 04 Nov 2017 No recent reports of development identified for phase-I development in Solid-tumours(Late-stage disease, Second-line therapy or greater) in USA (Parenteral)
  • 02 Jun 2017 Updated adverse events and efficacy data from a phase I trial in Solid tumours presented at the 53rd Annual Meeting of the American Society of Clinical Oncology (ASCO-2017)
  • 24 Jan 2017 Phase-I clinical trials in Ovarian cancer (Late-stage disease) in USA (IV) (NCT03011320)
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