STM 434

Drug Profile

STM 434

Alternative Names: STM-434

Latest Information Update: 22 Feb 2017

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At a glance

  • Originator Amgen
  • Developer Atara Biotherapeutics
  • Class Antibodies; Antineoplastics; Recombinant fusion proteins
  • Mechanism of Action Activin inhibitors; Type-II-B activin receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Ovarian cancer; Solid tumours

Most Recent Events

  • 13 Jan 2017 Santa Maria Biotherapeutics completes a phase I trial in Solid tumours and Ovarian cancer (Late-stage disease, Combination therapy) in USA (NCT02262455)
  • 20 Oct 2015 STM 434 receives Orphan Drug status for Ovarian cancer in USA
  • 06 Aug 2015 STM 434 is still in phase I trials for Solid tumours, including Ovarian cancer in USA
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