Axicabtagene ciloleucel

Drug Profile

Axicabtagene ciloleucel

Alternative Names: KTE-C19; KTE-C19 CAR

Latest Information Update: 19 May 2017

Price : $50

At a glance

  • Originator Cabaret Biotech
  • Developer Genentech; Kite Pharma; National Cancer Institute (USA)
  • Class Antineoplastics; CAR-T cell therapies
  • Mechanism of Action CD19 antigen modulators; Gene transference; T lymphocyte replacements; T-cell receptor antigen modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Diffuse large B cell lymphoma; Chronic lymphocytic leukaemia; Mantle-cell lymphoma; Acute lymphoblastic leukaemia; Follicular lymphoma
  • New Molecular Entity No

Highest Development Phases

  • Preregistration Non-Hodgkin's lymphoma
  • Phase II Mantle-cell lymphoma
  • Phase I/II Acute lymphoblastic leukaemia
  • Phase I Leukaemia
  • Clinical Phase Unknown Diffuse large B cell lymphoma

Most Recent Events

  • 18 May 2017 Kite Pharma initiates an expanded access program for Non-Hodgkin's lymphoma (Refractory metastatic disease, Second-line therapy or greater) in USA (NCT03153462)
  • 18 Apr 2017 Kite Pharma plans to initiate the phase II ZUMA-5 trial in non-Hodgkin's lymphoma (Second-line therapy or greater) in USA (IV)
  • 02 Apr 2017 Updated primary analysis of efficacy data from the phase I/II ZUMA-1 trial in Non-Hodgkin Lymphoma released by Kite Pharma
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