Acalabrutinib

Drug Profile

Acalabrutinib

Alternative Names: ACP-196

Latest Information Update: 31 Jan 2017

Price : $50

At a glance

  • Originator Acerta Pharma
  • Developer Acerta Pharma; Merck Sharp & Dohme
  • Class Antineoplastics; Benzamides; Heavy metals; Imidazoles; Pyrazines; Pyridines; Pyrrolidines; Small molecules
  • Mechanism of Action Agammaglobulinaemia tyrosine kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Mantle-cell lymphoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Chronic lymphocytic leukaemia
  • Phase II Bladder cancer; Head and neck cancer; Mantle-cell lymphoma; Non-small cell lung cancer; Ovarian cancer; Pancreatic cancer; Rheumatoid arthritis
  • Phase I/II B cell lymphoma; B cell prolymphocytic leukaemia; Glioblastoma; Waldenstrom's macroglobulinaemia
  • Phase I Diffuse large B cell lymphoma; Follicular lymphoma; Multiple myeloma

Most Recent Events

  • 05 Dec 2016 Updated preliminary efficacy and adverse events data from a phase I/II trial in Chronic lymphocytic leukaemia presented at the 58th Annual Meeting and Exposition of the American Society of Hematology (ASH-Hem-2016)
  • 03 Dec 2016 Pharmacodynamics data from a preclinical study in B-cell lymphoma presented at the 58th Annual Meeting and Exposition of the American Society of Haematology (ASH-2016)
  • 21 Nov 2016 Acerta Pharma plans a phase III trial for Mantle cell lymphoma (Combination therapy, First-line therapy, In the elderly) in USA, Argentina, Australia, Belgium, Brazil, Canada, Czech Republic, France, Germany, Greece, Hungary, Israel, Italy, Mexico, Peru, Poland, Romania, Russia, South Korea, Spain, Taiwan, Ukraine and Vietnam (PO) (NCT02972840)
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