Research programme: kinase modulators - Blueprint Medicines

Drug Profile

Research programme: kinase modulators - Blueprint Medicines

Alternative Names: BLU 6864; BLU 9931; BLU-667; c-KIT D816V inhibitor - Blueprint Medicines; Fibroblast growth factor receptor 4 (FGFR4) selective inhibitor - Blueprint Medicines; Highly selective kinase drugs for specific genomically-defined cancer patients - Blueprint Medicines; Kinase inhibitors - Blueprint Medicines; KIT D816V selective inhibitor - Blueprint Medicines; NTRK inhibitors; Phosphotransferase inhibitors - Blueprint Medicines; PRKACA inhibitors - Blueprint Medicines; Protein kinase cAMP-activated catalytic subunit alpha (PRKACA) fusions inhibitors; RET fusion inhibitors - Blueprint Medicines; RET inhibitors - Blueprint Medicines; TrkA inhibitors; Type 4 fibroblast growth factor receptor (FGFR4) antagonists - Blueprint Medicines

Latest Information Update: 02 Feb 2017

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At a glance

  • Originator Blueprint Medicines
  • Class Small molecules
  • Mechanism of Action Advanced glycosylation end product modulators; Fusion oncogene protein inhibitors; Phosphotransferase inhibitors; Protein kinase inhibitors; Protein kinase modulators; Proto oncogene protein c-kit inhibitors; Receptor protein-tyrosine kinase antagonists; TrkA receptor antagonists; Type 4 fibroblast growth factor receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Cancer; Gastrointestinal stromal tumours; Hepatocellular carcinoma; Mastocytosis
  • Research Inborn genetic disorders

Most Recent Events

  • 27 Jan 2017 Blueprint Medicines Corporation plans a first-in-human phase I trial for Non-small cell lung cancer (Second-line therapy or greater, Late-stage disease, Inoperable/Unresectable, Metastatic disease), Thyroid cancer and Solid tumours (Second-line therapy or greater, Late-stage disease, Inoperable/Unresectable) in USA (PO) (NCT03037385)
  • 17 Mar 2016 Interim pharmacodynamics data from preclinical studies in Cancer released by Blueprint Medicines
  • 15 Mar 2016 Blueprint Medicines and Roche enter into a worldwide collaboration and exclusive license agreement for the discovery, development and commercialization of up to five small molecule therapeutics targeting kinases
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