Drug Profile


Alternative Names: ALN AT3; ALN-AT3SC; SAR 439774

Latest Information Update: 14 Sep 2017

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At a glance

  • Originator Alnylam Pharmaceuticals
  • Developer Alnylam Pharmaceuticals; Sanofi Genzyme
  • Class Antifibrinolytics; Antihaemorrhagics; Antisense RNA; Drug conjugates; Small interfering RNA
  • Mechanism of Action Antithrombin III inhibitors; Haemostasis stimulants; RNA interference
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Haemophilia A; Haemophilia B
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Haemophilia A; Haemophilia B

Most Recent Events

  • 08 Sep 2017 Adverse events data from a phase II trial in Haemophilia A and Haemophilia B released by Alnylam
  • 07 Sep 2017 Alnylam suspends dosing of patients in the phase II OLE trial in Haemophilia B and Haemophilia B in Russia, USA, Switzerland, Bulgaria, United Kingdom due to a fatal thrombotic event (SC) (NCT02554773)
  • 07 Sep 2017 Alnylam suspends planned dosing of patients in the phase III ATLAS programme in Haemophilia A and Haemophilia B in USA due to a fatal thrombotic event (SC)
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