ONC 201 - Oncoceutics

Drug Profile

ONC 201 - Oncoceutics

Alternative Names: NSC-350625; ONC201; ONC201 - Oncoceutics; TIC 10; TRAIL-inducing compound 10 (TIC10) - Oncoceutics

Latest Information Update: 04 May 2017

Price : $50

At a glance

  • Originator Oncoceutics
  • Developer National Institutes of Health; Oncoceutics; Rutgers; University of Texas M. D. Anderson Cancer Center
  • Class Antineoplastics; Imidazoles; Pyrimidinones; Small molecules
  • Mechanism of Action Agammaglobulinaemia tyrosine kinase inhibitors; Dopamine D2 receptor antagonists; Dopamine D3 receptor antagonists; Extracellular signal-regulated MAP kinase inhibitors; Mitogen activated protein kinase 3 inhibitors; Proto oncogene protein c-akt inhibitors; Ras signal transduction pathway inhibitors; TRAIL receptor 1 agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Glioblastoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Glioblastoma
  • Phase I/II Acute lymphoblastic leukaemia; Acute myeloid leukaemia; Multiple myeloma; Myelodysplastic syndromes; Non-Hodgkin's lymphoma
  • Phase I Solid tumours
  • Preclinical Breast cancer; Colorectal cancer; Mantle-cell lymphoma; Pancreatic cancer
  • Research Endometrial cancer
  • Phase Unknown Neuroendocrine tumours

Most Recent Events

  • 25 Apr 2017 Oncoceutics initiates an expanded-access programme for Glioblastoma (Recurrent; Second-line therapy or greater) in USA (PO) (NCT03134131)
  • 24 Apr 2017 Pharmacodynamic results from a preclinical trial in Cancer reported at the 108th Annual Meeting of the American Association for Cancer Research (AACR-2017)
  • 10 Apr 2017 Fox Chase Cancer Center and Oncoceutics plan a phase II trial for Endometrial cancer (Metastatic disease, Recurrent) (NCT03099499)
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