ONC 201 - Oncoceutics

Drug Profile

ONC 201 - Oncoceutics

Alternative Names: NSC-350625; ONC201; ONC201 - Oncoceutics; TIC 10; TRAIL-inducing compound 10 (TIC10) - Oncoceutics

Latest Information Update: 31 Jul 2017

$50 / €47 *
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At a glance

  • Originator Oncoceutics
  • Developer Fox Chase Cancer Center; Oncoceutics; Rutgers; University of Texas M. D. Anderson Cancer Center
  • Class Antineoplastics; Imidazoles; Pyrimidinones; Small molecules
  • Mechanism of Action Agammaglobulinaemia tyrosine kinase inhibitors; Dopamine D2 receptor antagonists; Dopamine D3 receptor antagonists; Extracellular signal-regulated MAP kinase inhibitors; Mitogen activated protein kinase 3 inhibitors; Proto oncogene protein c-akt inhibitors; Ras signal transduction pathway inhibitors; TRAIL receptor 1 agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Glioblastoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Endometrial cancer; Glioblastoma
  • Phase I/II Acute lymphoblastic leukaemia; Acute myeloid leukaemia; Multiple myeloma; Myelodysplastic syndromes; Non-Hodgkin's lymphoma
  • Phase I Solid tumours
  • Preclinical Breast cancer; Colorectal cancer; Mantle-cell lymphoma; Pancreatic cancer
  • Phase Unknown Neuroendocrine tumours

Most Recent Events

  • 08 Jun 2017 Phase-II clinical trials in Endometrial cancer (Metastatic disease, Recurrent, Second-line therapy or greater) in USA (PO) (NCT03099499)
  • 02 Jun 2017 Efficacy and adverse event data from a phase I trial in Solid tumours (Endometrial cancer) presented at 53rd Annual Meeting of the American Society of Clinical Oncology (ASCO-2017)
  • 02 Jun 2017 Interim efficacy, adverse events and immunology data from a phase I trial in Solid tumours presented at the 53rd Annual Meeting of the American Society of Clinical Oncology (ASCO-2017)
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