ONC 201 - Oncoceutics

Drug Profile

ONC 201 - Oncoceutics

Alternative Names: NSC-350625; ONC201; ONC201 - Oncoceutics; TIC 10; TRAIL-inducing compound 10 (TIC10) - Oncoceutics

Latest Information Update: 03 Feb 2017

Price : $50

At a glance

  • Originator Oncoceutics
  • Developer Fox Chase Cancer Center; Oncoceutics; Rutgers; University of Texas M. D. Anderson Cancer Center
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Dopamine D2 receptor antagonists; Dopamine D3 receptor antagonists; Extracellular signal-regulated MAP kinase inhibitors; Proto oncogene protein c-akt inhibitors; Ras signal transduction pathway inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Glioblastoma
  • Phase I/II Acute lymphoblastic leukaemia; Acute myeloid leukaemia; Myelodysplastic syndromes; Non-Hodgkin's lymphoma
  • Phase I Multiple myeloma; Solid tumours
  • Preclinical Colorectal cancer; Mantle-cell lymphoma
  • Phase Unknown Neuroendocrine tumours

Most Recent Events

  • 25 Jan 2017 Investigation in Neuroendocrine tumours in USA (PO) before January 2017
  • 25 Jan 2017 Case Comprehensive Cancer Center plans a phase II trial for Neuroendocrine tumours, including pheochromocytoma-paraganglioma (Recurrent, Metastatic disease, Second-line or greater therapy) in USA (PO) (NCT03034200)
  • 06 Dec 2016 Pharmacodynamic results from a preclinical trial in Acute myeloid leukaemia and Multiple myeloma reported at the 58th Annual Meeting and Exposition of the American Society of Hematology (ASH-Hem-2016)
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