ONC 201 - Oncoceutics

Drug Profile

ONC 201 - Oncoceutics

Alternative Names: NSC-350625; ONC201; ONC201 - Oncoceutics; TIC 10; TRAIL-inducing compound 10 (TIC10) - Oncoceutics

Latest Information Update: 09 Nov 2017

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At a glance

  • Originator Oncoceutics
  • Developer Case Comprehensive Cancer Center; Fox Chase Cancer Center; Oncoceutics; Rutgers; University of Texas M. D. Anderson Cancer Center
  • Class Antineoplastics; Imidazoles; Pyrimidinones; Small molecules
  • Mechanism of Action Agammaglobulinaemia tyrosine kinase inhibitors; Dopamine D2 receptor antagonists; Dopamine D3 receptor antagonists; Extracellular signal-regulated MAP kinase inhibitors; Mitogen activated protein kinase 3 inhibitors; Proto oncogene protein c-akt inhibitors; Ras signal transduction pathway inhibitors; TRAIL receptor 1 agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Glioblastoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Endometrial cancer; Glioblastoma; Glioma; Neuroendocrine tumours
  • Phase I/II Acute lymphoblastic leukaemia; Acute myeloid leukaemia; Multiple myeloma; Myelodysplastic syndromes; Non-Hodgkin's lymphoma
  • Phase I Solid tumours
  • Preclinical Breast cancer; Colorectal cancer; Mantle-cell lymphoma; Pancreatic cancer

Most Recent Events

  • 31 Oct 2017 Phase-II clinical trials in Glioma (Recurrent, Late-stage disease) in USA (PO) (NCT03295396)
  • 03 Oct 2017 Oncoceutics plans a phase II trial for Glioma in USA (NCT03295396)
  • 27 Sep 2017 Oncoceutics receives SBIR grant from National Institutes of Health for ONC 201 development in Endometrial cancer
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