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Obefazimod - Abivax

Drug Profile

Obefazimod - Abivax

Alternative Names: ABX-464; SPL-464

Latest Information Update: 14 Feb 2024

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At a glance

  • Originator Splicos
  • Developer Abivax
  • Class Amines; Anti-inflammatories; Antirheumatics; Antivirals; Chlorobenzenes; Fluorobenzenes; Quinolines; Small molecules
  • Mechanism of Action MiRNA-124 expression stimulants; RNA cap-binding protein modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Ulcerative colitis
  • Phase II/III COVID 2019 infections
  • Phase II Rheumatoid arthritis
  • Phase I Crohn's disease
  • Discontinued HIV infections

Most Recent Events

  • 13 Feb 2024 Abivax plans a phase IIb trial for Crohn's disease in the third quarter of 2024
  • 31 Oct 2023 Abivax plans a clinical trial for Ulcerative colitis (Combination therapy) in 2025 (Abivax pipeline, October 2023)
  • 14 Oct 2023 Efficacy and adverse events data from a phase IIb trial in Ulcerative colitis presented at the 31st United European Gastroenterology Week (UEG-2023)
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