Drug Profile


Alternative Names: AG 120

Latest Information Update: 05 Oct 2017

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At a glance

  • Originator Agios Pharmaceuticals
  • Class Antineoplastics; Cyclobutanes; Nitriles; Pyridines; Pyrrolidines; Small molecules
  • Mechanism of Action Isocitrate dehydrogenase 1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia; Cholangiocarcinoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Acute myeloid leukaemia; Cholangiocarcinoma
  • Phase I Glioma; Myelodysplastic syndromes; Solid tumours

Most Recent Events

  • 22 Sep 2017 Agios Pharmaceuticals plans a phase I trial in Healthy volunteers in USA (PO) (NCT03282513)
  • 01 Sep 2017 Agios Pharmaceuticals initiates enrolment in a phase I trial in Healthy volunteers in USA (PO) (NCT03282513)
  • 07 Aug 2017 Agios Pharmaceuticals initiates an expanded-access programme for Acute myeloid leukaemia (Monotherapy, Second-line therapy or greater, In children, In adolescents, In adults, In the elderly) (PO) (NCT03245424)
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