Drug Profile


Alternative Names: ASK1 inhibitor - Gilead Sciences; GS-4977; GS-4997

Latest Information Update: 09 Mar 2017

Price : $50

At a glance

  • Originator Gilead Sciences
  • Class Cardiovascular therapies
  • Mechanism of Action MAP kinase kinase kinase 5 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Non-alcoholic steatohepatitis
  • Phase II Alcoholic hepatitis; Diabetic nephropathies; Non-alcoholic fatty liver disease; Pulmonary arterial hypertension

Most Recent Events

  • 27 Feb 2017 Gilead Sciences has patent protection for selonsertib in USA and Europe (Gilead Sciences 10-K, February 2017)
  • 01 Feb 2017 Phase-III clinical trials in Non-alcoholic steatohepatitis in USA (PO) (NCT03053063)
  • 01 Dec 2016 Gilead Sciences completes the phase II ARROW trial in Pulmonary arterial hypertension in USA, United Kingdom, the Netherlands, Canada, France, Germany, Italy and Spain (NCT02234141)
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