Selonsertib - Gilead Sciences

Drug Profile

Selonsertib - Gilead Sciences

Alternative Names: ASK1 inhibitor - Gilead Sciences; GS-4977; GS-4997

Latest Information Update: 21 Nov 2017

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At a glance

  • Originator Gilead Sciences
  • Class Benzamides; Cardiovascular therapies; Imidazoles; Pyridines; Triazoles
  • Mechanism of Action MAP kinase kinase kinase 5 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Non-alcoholic steatohepatitis
  • Phase II Alcoholic hepatitis; Diabetic nephropathies; Non-alcoholic fatty liver disease; Pulmonary arterial hypertension

Most Recent Events

  • 09 Sep 2017 Efficacy and adverse events data from the phase II ARROW trial in Pulmonary arterial hypertension presented at the 27th Annual Congress of the European Respiratory Society (ERS-2017)
  • 19 Apr 2017 Phase-I clinical trials in Non-alcoholic steatohepatitis (Combination therapy, In volunteers) in USA (PO) before April 2017
  • 19 Apr 2017 Pharmacokinetics and adverse events data from a phase I trial in Non-alcoholic steatohepatitis presented at The International Liver Congress 2017 (ILC-2017)
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