Drug Profile


Alternative Names: ABBV-399; ABT 399

Latest Information Update: 25 Sep 2017

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At a glance

  • Originator AbbVie
  • Developer AbbVie; Bristol-Myers Squibb
  • Class Antineoplastics; Auristatins; Immunoconjugates; Immunotoxins; Monoclonal antibodies
  • Mechanism of Action Mitosis inhibitors; Proto oncogene protein c met inhibitors; Tubulin inhibitors; Tubulin polymerisation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Non-small cell lung cancer; Solid tumours

Most Recent Events

  • 18 Oct 2017 AbbVie plans a phase I trial for Solid tumours (Late-stage disease) in Japan (IV) in November 2017 (NCT03311477)
  • 22 Sep 2017 Phase-I clinical trials in Non-small cell lung cancer (Second-line therapy or greater, Combination therapy, Late-stage disease) (IV)
  • 02 Jun 2017 Adverse events, efficacy data from a phase I trial in Solid tumours presented at the 53rd Annual Meeting of American Society of Clinical Oncology (ASCO-2017)
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