Drug Profile


Alternative Names: ARRY 470; LOXO-101

Latest Information Update: 13 Jul 2017

Price : $50

At a glance

  • Originator Array BioPharma
  • Developer Array BioPharma; Loxo Oncology
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Tropomyosin-related kinase antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Soft tissue sarcoma; Solid tumours
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Solid tumours
  • Phase I/II CNS cancer
  • Preclinical Acute lymphoblastic leukaemia

Most Recent Events

  • 10 Jul 2017 National Cancer Institute plans a phase II trial for Solid tumours, Non Hodgkin lymphoma, Histiocytosis (In infants, In children, In adolescents, In adults, with NTRK fusions, Second-line therapy or greater) in USA (PO) (NCT03213704)
  • 03 Jun 2017 Efficacy data from a phase I/II trial in Solid tumours released by Solid tumours
  • 03 Jun 2017 Pooled efficacy and adverse data from a phase I trial, phase II NAVIGATE and phase I/II SCOUT trial in Solid tumours released by Lox Oncology
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