Drug Profile


Alternative Names: LOXO-101

Latest Information Update: 15 May 2017

Price : $50

At a glance

  • Originator Array BioPharma
  • Developer Array BioPharma; Loxo Oncology
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Tropomyosin-related kinase antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Solid tumours; Soft tissue sarcoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Solid tumours
  • Phase I/II CNS cancer
  • Preclinical Acute lymphoblastic leukaemia

Most Recent Events

  • 12 May 2017 Larotrectinib receives Orphan Drug status for Solid tumours (In patients with tropomyosin receptor kinase fusions) in USA
  • 24 Feb 2017 Loxo Oncology collaborates with NCI Formulary to co-develop larotrectinib in Cancer
  • 16 Jan 2017 Loxo Oncology initiates an expanded-access programme for Cancer in USA (PO, Capsule and PO, Liquid) (NCT03025360)
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